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5‐Bromobenzofuran Analog of Chloramphenicol
Author(s) -
Bevinakatti Hanamanthsa S.,
Badiger Virupax V.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190111
Subject(s) - chemistry , fragmentation (computing) , propane , diol , chloramphenicol , medicinal chemistry , stereochemistry , organic chemistry , antibiotics , biochemistry , computer science , operating system
dl‐threo ‐2‐Dichloroacetamido‐1‐[2‐(5‐bromobenzofuranyl)] propane‐1, 3‐diol ( 7 ) was synthesised according to Sorm's method. The fragmentation of 2‐dichloroacetamido‐3‐hydroxy‐1‐[2‐(5‐bromobenzofuranyl)[‐1‐propanone ( 6 ) under electron impact is reported. The base peak is due to the rupture of the central bond whereas loss of water and McLafferty rearrangement also lead to important fragmentation pathways.