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Monoamine oxidase and succinate dehydrogenase inhibitory properties of substituted 1,3,4‐oxadiazole‐2‐thiones
Author(s) -
Soni Namita,
Barthwal J. P.,
Saxena A. K.,
Bhargava K. P.,
Parmar S. S.
Publication year - 1982
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570190103
Subject(s) - chemistry , monoamine oxidase , succinate dehydrogenase , oxadiazole , in vitro , enzyme , dehydrogenase , inhibitory postsynaptic potential , monoamine neurotransmitter , biochemistry , nuclear chemistry , organic chemistry , serotonin , endocrinology , medicine , receptor
Fifteen new 3‐arylaminomethyl‐5‐(2‐hydroxy‐3,5‐dibromophenyl)‐1,3,4‐oxadiazole‐2‐thiones were synthesized and characterized by their sharp melting points, elemental analyses and ir spectra. These substituted oxadiazolylthiones were evaluated for their enzyme inhibitory activity. All compounds inhibited in vitro monoamine oxidase and succinate dehydrogenase activity of rat brain homogenates. The degree of monoamine oxidase inhibition ranged from 59‐93% at a final concentration of 1 × 10 −4 M whereas the inhibition of succinate dehydrogenase was 49‐100% at a final concentration of 5 × 10 −5 M .