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Fluorine containing bioactive heterocycles. Part II . Synthesis of some new fluorine containing arylglyoxals, their hydrates and 1,5‐disubstituted hydantoins
Author(s) -
Joshi Krishna C.,
Pathak Vijai N.,
Goyal Mahendra K.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180836
Subject(s) - chemistry , fluorine , benzene , condensation , nuclear chemistry , organic chemistry , thermodynamics , physics
Eight new fluorine containing arylglyoxals have been synthesized by the oxidation of the active methyl group of fluorinated acetophenones by selenium dioxide in dioxan‐water medium. The corresponding hydrates were obtained by dissolving arylglyoxals in minimum amounts of benzene and adding hot water. Seventeen new fluorine containing 1,5‐disubstituted hydantoins were subsequently prepared by the condensation of these arylglyoxals with arylureas in ethanol and characterized by ir, pmr and mass spectral studies. Representative compounds have been screened for their possible anticonvulsant and analgesic activities. None of the compounds show significant analgesic acitivity.