Functionalization of substituted 2‐(1 H )pyridones. II. Synthetic pathways to c‐6 modified 3‐cyano‐ and 3‐carboxy‐2‐(1 H )pyridones from a common precursor | Zendy

Showalter H. D. Hollis | Zendy; Domagala John M. | Zendy; Sanchez Joseph P. | Zendy

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Functionalization of substituted 2‐(1 H )pyridones. II. Synthetic pathways to c‐6 modified 3‐cyano‐ and 3‐carboxy‐2‐(1 H )pyridones from a common precursor

Author(s) -

Showalter H. D. Hollis,

Domagala John M.,

Sanchez Joseph P.

Publication year - 1981

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570180825

Subject(s) - chemistry , surface modification , substituent , combinatorial chemistry , stereochemistry , organic chemistry

Starting from readily available 1,2‐dihydro‐6‐methyl‐2‐oxo‐3‐pyridinecarbonitrile, 1, viable synthetic pathways to a number of C‐6 functionalized 1,2‐dihydro‐2‐oxo‐3‐pyridinecarbonitriles and corresponding acids are presented. Through the utilization of dianion chemistry, the C‐6 methyl substituent is selectively functionalized to three different oxidation levels.

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