Premium
Functionalization of substituted 2‐(1 H )pyridones. II. Synthetic pathways to c‐6 modified 3‐cyano‐ and 3‐carboxy‐2‐(1 H )pyridones from a common precursor
Author(s) -
Showalter H. D. Hollis,
Domagala John M.,
Sanchez Joseph P.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180825
Subject(s) - chemistry , surface modification , substituent , combinatorial chemistry , stereochemistry , organic chemistry
Starting from readily available 1,2‐dihydro‐6‐methyl‐2‐oxo‐3‐pyridinecarbonitrile, 1, viable synthetic pathways to a number of C‐6 functionalized 1,2‐dihydro‐2‐oxo‐3‐pyridinecarbonitriles and corresponding acids are presented. Through the utilization of dianion chemistry, the C‐6 methyl substituent is selectively functionalized to three different oxidation levels.