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Mutagenic heterocyclic nitrogen compounds related to protein pyrolysates. 1 . Derivatives of dipyrido[1,2‐ a :3′,2′‐ d ]imidazole
Author(s) -
SaintRuf G.,
Loukakou B.,
N'Zouzi C.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180816
Subject(s) - chemistry , imidazole , nitration , ring (chemistry) , heterocyclic compound , stereochemistry , nitrogen , quinoxaline , medicinal chemistry , organic chemistry
2‐Amino‐6‐methyldipyrido[1,2‐ a :3′‐2′‐ d ]imidazole is one of the mutagenic principles of L‐glutamic acid and casein pyrolysates. We prepared several isomeric amines of this compound, as well as their homologues methylated in different positions on the heterocyclic ring, either by nitration of the ring followed by reduction or from appropriate 4‐azidodipyrido[1,2‐ a :3′,2′‐ d ]imidazoles. The latter compounds, the heterocyclic ring itself and various functional derivatives (hydroxylated, carboxylated, hydrazinic) were synthesized from 2‐aminoimidazo[1,2‐ a ]pyridines via various reactions which are described herein.