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Addition reactions of azoesters with 2‐thioquinazolinones
Author(s) -
Giannola Libera Italo,
Giammona Gaetano,
Carlisi Bianca,
Palazzo Salvatore
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180814
Subject(s) - chemistry , thiourea , inert , diethyl azodicarboxylate , solvent , organic chemistry , mass spectrometry , inert gas , ethanol , chromatography , triphenylphosphine , catalysis
Reaction between diethyl azodicarboxylate (I) and 1,2,3,4‐tetrahydro‐2‐thioquinazolin‐4‐one (II), as a cyclic model of thiourea, both in alcoholic medium and in inert solvents has been investigated. By carrying out the reaction in an inert solvent, it was possible to isolate an intermediate. Evidence is presented that the intermediate, in turn, was converted into the final products. Structures were unequivocally assigned by mass spectrometry.