Conversion of 3,7‐Dialkoxy‐4 H ,8 H ‐benzo[l,2‐ c :4,5‐c']diisoxazole‐4,8‐dione into new heterocyclic systems | Zendy

Neidlein R. | Zendy; Throm S. | Zendy

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Conversion of 3,7‐Dialkoxy‐4 H ,8 H ‐benzo[l,2‐ c :4,5‐c']diisoxazole‐4,8‐dione into new heterocyclic systems

Author(s) -

Neidlein R.,

Throm S.

Publication year - 1981

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570180726

Subject(s) - chemistry , phosphorus pentachloride , nucleophile , medicinal chemistry , salt (chemistry) , alkali metal , potassium , sodium , chloride , organic chemistry , catalysis

Treatment of 1a or 1b with concentrated acids yielded the acid 3 , with alkali hydrogen carbonates the sodium salt 7 and the potassium salt 8 ; by reacting with phosphorus pentachloride the vinylogous acid chloride 9 was isolated. Reactions of 9 with amines such as N ‐nucleophiles led to the corresponding amides 10, 11, 14, 15 , and with alcohols such as O ‐nucleophiles to the corresponding alkoxyderivatives 16a, 16b , which are isomeric compounds to 1a, 1b and 2a, 2b.

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