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Synthesis of some 2‐amino‐4‐phenyl‐3 H ‐1,5‐benzodiazepines by reaction of aromatic diamines and acetylenic imidates
Author(s) -
Unangst Paul C.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180640
Subject(s) - chemistry , conjugated system , solvent , organic chemistry , medicinal chemistry , reaction conditions , catalysis , polymer
The reaction of several aromatic 1,2‐diamines with conjugated acetylenic imidate salts is described. The use of hexamethylphosphoric triamide (HMPA) as the solvent allows preparation of 2‐amino‐4‐phenyl‐3 H ‐1,5‐benzodiazepines in a one‐step reaction.
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