Synthesis and biological activity of some new 3‐and 6‐substituted coumarin amino acid derivatives. Part I | Zendy

ElNaggar A. M. | Zendy; Ahmed F. S. M. | Zendy; ElSalam A. M. Abd | Zendy; Radi M. A. | Zendy; Latif M. S. A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis and biological activity of some new 3‐and 6‐substituted coumarin amino acid derivatives. Part I

Author(s) -

ElNaggar A. M.,

Ahmed F. S. M.,

ElSalam A. M. Abd,

Radi M. A.,

Latif M. S. A.

Publication year - 1981

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570180627

Subject(s) - chemistry , dipeptide , coumarin , tosyl , thionyl chloride , organic chemistry , carbodiimide , antimicrobial , chloride , amino acid , biochemistry

The synthesis of 6‐nitrocouarrain‐3‐CO‐amino acids and their corresponding methyl esters (II‐XVII) and some dipeptide methyl esters (XVIII‐XXVI) are described. 6‐( N ‐Tosyl‐ or N ‐phthalylaminoacyl)aminocoumarin‐3‐carboxylic acid methyl esters (XXXIV‐XL) and 3‐( N ‐phthalyl‐ or N ‐tosylaminoacytyaminocoumarins (XLV‐LVI) have been prepared via the carbodiimide and acid chloride methods. Hydrazinolysis of 3‐ or 6‐( N ‐phthalylaminoacyl)aminocoumarin derivatives in tetraline gave the corresponding 3‐ and 6‐(aminoacyl)aminocoumarins and the carboxylic acid hydrazides (XLI‐LVIII), respectively. 3‐( N ‐Tosyl‐L‐Val‐L‐Leu‐)aminocoumarin (LIX) was synthesized via the azide method. Twenty four of various substituted 3‐ and 6‐aminoacylcoumarin derivatives were found to possess specific antimicrobial activities towards different microorganisms.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research