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Synthesis of anhydro‐3‐mercapto‐5‐pyrazinyl‐1,2,4‐triazolium hydroxides
Author(s) -
Shutske Gregory M.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180533
Subject(s) - chemistry , combinatorial chemistry , 1,2,4 triazole , organic chemistry
The synthesis of some novel anhydro‐3‐mercapto‐5‐pyrazinyl‐1,2,4‐triazolium hydroxides 5 is described. The appropriate 1‐methylhydrazides 3 were condensed with isothiocyanates to give the thiosemicarbazides 4 which were cyclized to 5 under mildly basic conditions. A few 1,2,4‐triazole‐3‐thiones 8 were synthesized for comparison, starting with the 2‐methylhydrazides 6 and then carrying out analogous synthetic transformations.