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Synthesis of 6‐benzyl‐ and 6‐phenethyl‐2,4‐diamino‐5,6,7,8‐tetrahydropyrimido[4,5‐ d ]pyrimidines
Author(s) -
Delia Thomas J.,
Sami Salah M.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180516
Subject(s) - chemistry , phenethylamines , formaldehyde , mannich reaction , organic chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , catalysis
The preparation of ten aralkyl derivatives of 2,4‐diamino‐5,6,7,8‐tetrahydropyrimido[4,5‐ d ]pyrimidines ( 6 ) has been accomplished. The title compounds were prepared in a simple one step reaction from 2,4,6‐triaminopyrimidine ( 4 ), formaldehyde ( 2 ), and either substituted benzylamines ( 1a‐d ) or substituted phenethylamines ( 1e‐j ). This modified Mannich reaction has been shown to be a general method for such derivatives. Elemental analysis, 1 H nmr and mass spectral data have confirmed the proposed structures. None of the compounds exhibited either antimalarial or antitrypanosomal activity.