Premium
Transformations in the 2‐quinolone series
Author(s) -
Coppola Gary M.,
Hardtmann Goetz E.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180513
Subject(s) - chemistry , nucleophile , quinoline , sulfur , quinolone , nitro , phosphorus , nitrogen , carbon fibers , organic chemistry , oxygen , medicinal chemistry , antibiotics , biochemistry , alkyl , materials science , composite material , composite number , catalysis
The treatment of 1‐substituted‐1,2‐dihydro‐4‐hydroxy‐2‐oxo‐3‐quinoline carboxylic acid esters and 4‐hydroxy‐1‐methyl‐3‐nitro‐2‐(1 H )quinolinone with phosphorus oxychloride resulted in the formation of the corresponding 4‐chloro‐2‐quinolones. Their reactions with a variety of carbon, nitrogen, oxygen, and sulfur nucleophiles is described.