Transformations in the 2‐quinolone series | Zendy

Coppola Gary M. | Zendy; Hardtmann Goetz E. | Zendy

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Transformations in the 2‐quinolone series

Author(s) -

Coppola Gary M.,

Hardtmann Goetz E.

Publication year - 1981

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570180513

Subject(s) - chemistry , nucleophile , quinoline , sulfur , quinolone , nitro , phosphorus , nitrogen , carbon fibers , organic chemistry , oxygen , medicinal chemistry , antibiotics , biochemistry , alkyl , materials science , composite material , composite number , catalysis

The treatment of 1‐substituted‐1,2‐dihydro‐4‐hydroxy‐2‐oxo‐3‐quinoline carboxylic acid esters and 4‐hydroxy‐1‐methyl‐3‐nitro‐2‐(1 H )quinolinone with phosphorus oxychloride resulted in the formation of the corresponding 4‐chloro‐2‐quinolones. Their reactions with a variety of carbon, nitrogen, oxygen, and sulfur nucleophiles is described.

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