Premium
The reaction of nitriles with mercaptoacetic acid. A new synthesis of thiazole derivatives
Author(s) -
Elnagdi Mohamed Hilmy,
Khalifa Mohamed Ali Elsayed,
Ibraheim Mohamed Kamal Ahmed,
Elmoghayar Mohamed Riffat Hamza
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180505
Subject(s) - chemistry , thiazole , benzonitrile , reagent , derivative (finance) , organic chemistry , ethyl cyanoacetate , catalysis , malononitrile , financial economics , economics
The reaction of mercaptoacetic acid with nitriles was investigated. Whereas 4‐hydroxythiazole derivative could be obtained from the reaction of benzoylacetonitrile and of ethyl cyanoacetate with mercaptoacetic acid, a bithiazole derivative was obtained on treatment of benzonitrile with the same reagent. The behaviour of the synthesised thiazole derivatives towards aromatic aldehydes and hydrazines is reported.