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Synthesis of a non‐flexible analog of chlorpromazine
Author(s) -
Elliott Arthur J.,
Guzik Henry
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180501
Subject(s) - chemistry , phenothiazine , chlorpromazine , stereochemistry , combinatorial chemistry , pharmacology , medicine
9‐Chloro‐2‐dimethylaminomethyl‐1,2‐dihydropyrrolo[3,2,1‐ kl ]phenothiazine ( 3b ), a conformationally restricted analog of chlorpromazine, has been synthesised and has been found to be devoid of neuroleptic activity.