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An improvement in the synthesis of ethyl pyrimidinecarbamates
Author(s) -
Auzou Gilles,
Rips Richard
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180445
Subject(s) - chemistry , pyridinium , yield (engineering) , pyridine , dimethylformamide , condensation , solvent , chloride , salt (chemistry) , organic chemistry , materials science , physics , metallurgy , thermodynamics
It is demonstrated that N ‐(ethoxycarbony])pyridinium chloride ( 3 ) is the reactive agent in the synthesis of 4‐ethoxycarbonylamino‐2,6‐dimethylpyrimidine ( 1 ). A good yield (80%) of 1 may be obtained by the condensation of 3 with excess 4‐amino‐2,6‐dimethylpyrimidine using pyridine or dimethylformamide as the solvent. A method allowing for the preparation of 4‐ethoxycarbonylamino‐x‐hydroxypyrimidines via the same process is offered.