Heterocyclic systems. II. Synthesis of 4 H ,6 H ‐pyrrolo[1,2‐ a ][4,1]benzoxazepine | Zendy

Massa Silvio | Zendy; Corelli Federico | Zendy; Stefancich Giorgio | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Heterocyclic systems. II. Synthesis of 4 H ,6 H ‐pyrrolo[1,2‐ a ][4,1]benzoxazepine

Author(s) -

Massa Silvio,

Corelli Federico,

Stefancich Giorgio

Publication year - 1981

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570180442

Subject(s) - chemistry , sodium borohydride , lithium (medication) , intramolecular force , aluminum hydride , pyrrole , medicinal chemistry , stereochemistry , borohydride , combinatorial chemistry , organic chemistry , ion , catalysis , medicine , methoxide , endocrinology

The reduction of 1‐(2‐methoxycarbonylphenyl)pyrrole‐2‐carboxaldehyde by lithium aluminum hydride led to 1‐(2‐hydroxymethylphenyl)‐2‐hydroxymethylpyrrole, which was in turn transformed into 4 H ,6 H ‐pyrrolo‐[1,2‐ a ][4,1]benzoxazepine through intramolecular dehydration. The reductive action of sodium borohydride, instead, allowed the preparation of 6‐oxo‐4 H ‐pyrrolo[1,2‐ a ][4,1]benzoxazepine.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research