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Synthesis of the novel isoquinoline enamide alkaloid polycarpine
Author(s) -
Lenz George R.,
Woo ChiMin
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180410
Subject(s) - isoquinoline , chemistry , alkaloid , stereochemistry
The synthesis of the novel enamide isoquinoline alkaloid polycarpine, ( Z )‐1‐(2′‐hydroxy‐3′,4′‐dimethoxy‐benzylidene)‐3,4‐dihydro‐6,7‐dimethoxy‐2‐(1H)isoquinolinecarboxaldehyde, proceeding from commercially available 2′,3′,4′‐trimethoxyacetophenone in seven steps is described. The O ‐methyl and O ‐benzyl derivatives were also obtained.