Anticonvulsant activity and succinate dehydrogenase inhibitory property of new substituted thiobarbiturates | Zendy

Dhasmana Anjali | Zendy; Barthwal J. P. | Zendy; Pandey B. R. | Zendy; Ali B. | Zendy; Bhargava K. P. | Zendy; Parmar S. S. | Zendy

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Anticonvulsant activity and succinate dehydrogenase inhibitory property of new substituted thiobarbiturates

Author(s) -

Dhasmana Anjali,

Barthwal J. P.,

Pandey B. R.,

Ali B.,

Bhargava K. P.,

Parmar S. S.

Publication year - 1981

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570180341

Subject(s) - chemistry , succinate dehydrogenase , pentylenetetrazol , anticonvulsant , inhibitory postsynaptic potential , in vitro , toxicity , dehydrogenase , aryl , pharmacology , stereochemistry , biochemistry , enzyme , organic chemistry , medicine , epilepsy , alkyl , neuroscience , biology

Eight 1‐aryl‐3‐(2‐pyridyl)thiobarbiturates were synthesized and evaluated for their anticonvulsant property and their ability to inhibit succinate dehydrogenase activity of rat brain homogenates. These substituted thiobarbiturates (100 mg./kg., i.p.) provided 20–60% protection against pentylenetetrazol‐induced convulsions in albino mice. Low toxicity of these compounds was reflected by their high approximate LD 50 values which were found to range from 500–1000 mg./kg. All substituted thiobarbiturates (Im M ) inhibited in vitro succinate dehydrogenase activity and the degree of inhibition ranged from 10–72%.

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