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1,2,4‐triazines. 1 . A convenient synthesis of 4,5‐dihydro‐1,2,4‐triazin‐3‐(2 H )one and its 6‐substituted derivatives
Author(s) -
Nakayama Yoshinori,
Sanemitsu Yuzuru,
Mizutani Masato,
Yoshioka Hirosuke
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180339
Subject(s) - chemistry , sodium borohydride , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
A facile synthesis of 4,5‐dihydro‐1,2,4‐triazin‐3‐(2 H )one (2a) from 5‐methylthio‐1,2,4‐triazin‐3‐(2 H )one (1a) with sodium borohydride is described. The reaction provides a convenient method for its 6‐substituted derivatives (2b‐h).

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