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Synthesis and antihypertensive properties of a novel series of 3‐substituted amino‐s‐triazolo[3,4‐α]phthalazine derivatives
Author(s) -
Omar A.Mohsen M. E.,
Kasem M. Gabr,
Laabota I. M.,
Bourdais J.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180311
Subject(s) - phthalazine , chemistry , aryl , series (stratigraphy) , combinatorial chemistry , organic chemistry , alkyl , paleontology , biology
A novel series of 3‐substituted amino‐ s ‐triazolo[3,4‐ a ]phthalazine derivatives has been synthesized by the one‐pot cyclodesulfurization reactions utilizing 1‐hydrazinophthalazine, alkyl, aryl, or aralkylisothiocyanates and dicyclohexylcarbodiimide (DCCD) mixtures. The products did not exhibit any antihypertensive properties. Their pmr and mass spectral analysis is given.