Premium
Studies in the heterocyclic series. XIX. Synthesis of 1,4‐diazaphenothiazine and its benzo derivatives
Author(s) -
Okafor Charles O.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180235
Subject(s) - chemistry , phenothiazine , ring (chemistry) , stereochemistry , series (stratigraphy) , medicinal chemistry , organic chemistry , medicine , pharmacology , paleontology , biology
1,4‐Diazaphenothiazine, the parent compound of this heterocyclic ring has now been prepared from 2,3‐dichloropyrazine and 2‐aminothiophenol. Replacement of 2,3‐dichloropyrazine with 2,3‐dichloroquinoxaline and 2,3,6‐trichloroquinoxaline led to the corresponding 1,4‐diazabenzo[ b ]phenothiazine in good yields. Structural assignments were made by spectroscopic studies and by certain chemical transformations.