Displacement‐cyclization reactions of mono‐substituted hydrazines with chloronitrobenzenes and chloronitropyrimidines. New routes to 8‐azapurine and benzopyrazole derivatives | Zendy

Defusco A. A. | Zendy; Strauss M. J. | Zendy

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Displacement‐cyclization reactions of mono‐substituted hydrazines with chloronitrobenzenes and chloronitropyrimidines. New routes to 8‐azapurine and benzopyrazole derivatives

Author(s) -

Defusco A. A.,

Strauss M. J.

Publication year - 1981

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570180225

Subject(s) - chemistry , hydrazine (antidepressant) , substituent , reactivity (psychology) , displacement (psychology) , group (periodic table) , medicinal chemistry , stereochemistry , organic chemistry , chromatography , alternative medicine , medicine , pathology , psychology , psychotherapist

Reactions of different chloronitrobenzenes and chloronitropyrimidines with monosubstituted hydrazines, R‐NHNH 2 , where R is methyl, carbomethoxy and phenyl, are described. The reactivity of these hydrazines in displacement‐ ortho substituent cyclizations varies substantially, depending on the nature of the aromatic substrate and the hydrazine R group. New routes to 8‐azapurine and benzopyrazole derivatives are decribed.

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