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Displacement‐cyclization reactions of mono‐substituted hydrazines with chloronitrobenzenes and chloronitropyrimidines. New routes to 8‐azapurine and benzopyrazole derivatives
Author(s) -
Defusco A. A.,
Strauss M. J.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180225
Subject(s) - chemistry , hydrazine (antidepressant) , substituent , reactivity (psychology) , displacement (psychology) , group (periodic table) , medicinal chemistry , stereochemistry , organic chemistry , chromatography , alternative medicine , medicine , pathology , psychology , psychotherapist
Reactions of different chloronitrobenzenes and chloronitropyrimidines with monosubstituted hydrazines, R‐NHNH 2 , where R is methyl, carbomethoxy and phenyl, are described. The reactivity of these hydrazines in displacement‐ ortho substituent cyclizations varies substantially, depending on the nature of the aromatic substrate and the hydrazine R group. New routes to 8‐azapurine and benzopyrazole derivatives are decribed.