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Tricyclic thiazolo[3,2‐ a ]thiapyrano[4,3‐ d ]pyrimidines and related analogs as potential anti‐inflammatory agents
Author(s) -
Rovnyak George,
Shu Virginia,
Schwartz Joseph
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180219
Subject(s) - chemistry , tricyclic , thiazoline , stereochemistry
A series of novel tricyclic thiazolo[3,2‐ a ]thiapyrano[4,3‐ d ]pyrimidines and related oxa, aza and carbo analogs of general formula 1 were prepared by a convenient addition‐cyclization reaction involving 2‐amino‐2‐thiazoline ( 4 ) and bisarylidene ketones of formula 3. Some of these compounds demonstrated antiinflammatory activity.