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Phase‐transfer catalysis in the N ‐benzylation of adenine
Author(s) -
Shinkai I.,
Vander Zwan M. C.,
Hartner F. W.,
Reamer R. A.,
Tull R. J.,
Weinstock L. M.
Publication year - 1981
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570180138
Subject(s) - chemistry , catalysis , halide , phase (matter) , phase transfer catalyst , alkylation , organic chemistry , medicinal chemistry
A convenient phase‐transfer catalysis in the N ‐benzylation of adenine is described. The benzylation of adenine with benzyl halides in a two‐phase system containing phase‐transfer catalyst gave 9‐benzylated adenines as a major product accompanied with 3‐benzylated adenines.