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Cyclic peptides from penicillium islandicum . A review and a reevaluation of the structure of islanditoxin
Author(s) -
Ghosh Anil C.,
Ramgopal Malathi
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170838
Subject(s) - chemistry , serine , cyclic peptide , stereochemistry , peptide , amino acid , penicillium , biochemistry , enzyme , food science
Dedicated to Professor John C. Sheehan on the occasion of his sixty‐fifth birthday. The structures of cyclochlorotine and islanditoxin, cyclic peptides from Penicillium islandicum are reviewed. The peptide A isolated in these laboratories has been identified by gc/ms studies as cyclochlorotine. It is suggested that the structure of islanditoxin [cyclo‐(L‐dichloroprolyl‐D‐β‐amino‐β‐phenylpropionyl‐L‐α‐amino‐ n ‐butyryl‐L‐seryl‐L‐serine)] 1 should now be revised to that of cyclochlorotine, [cyclo‐(L‐dichloroprolyl‐D‐β‐amino‐ n ‐butyryl‐L‐seryl‐L‐β‐amino‐β‐phenyl‐propionyl‐L‐serine)] 2 .