Cyclic peptides from penicillium islandicum . A review and a reevaluation of the structure of islanditoxin

Dedicated to Professor John C. Sheehan on the occasion of his sixty‐fifth birthday. The structures of cyclochlorotine and islanditoxin, cyclic peptides from Penicillium islandicum are reviewed. The peptide A isolated in these laboratories has been identified by gc/ms studies as cyclochlorotine. It is suggested that the structure of islanditoxin [cyclo‐(L‐dichloroprolyl‐D‐β‐amino‐β‐phenylpropionyl‐L‐α‐amino‐ n ‐butyryl‐L‐seryl‐L‐serine)] 1 should now be revised to that of cyclochlorotine, [cyclo‐(L‐dichloroprolyl‐D‐β‐amino‐ n ‐butyryl‐L‐seryl‐L‐β‐amino‐β‐phenyl‐propionyl‐L‐serine)] 2 .