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Synthesis of imidazo[4,5‐ b ]‐ and [4,5‐ c ]pyridines
Author(s) -
Middleton Richard W.,
Wibberley D. George
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170824
Subject(s) - chemistry , triethyl orthoformate , thiourea , urea , medicinal chemistry , organic chemistry , catalysis
2‐Arylimidazo[4,5‐ b ]‐ and [4,5‐ c ]pyridines have been prepared by treatment of the appropriate 2,3‐ or 3,4‐diaminopyridine with an aromatic carboxylic acid in the presence of polyphosphoric acid. Other derivatives have been prepared by similar cyclisation of diaminopyridines using triethyl orthoformate, urea, thiophosgene and thiourea and the properties of some N ‐oxides have been investigated. A number of the arylimidazopyridines have been screened for mutagenicity.