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Reaction of alkoxyuridines with ammonia
Author(s) -
Mathews Robert A.,
Stöhrer Gerhard
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170750
Subject(s) - chemistry , hydrogen sulfide , ammonia , pyrimidine , cytidine , alkoxy group , thio , alkylation , reaction conditions , combinatorial chemistry , organic chemistry , sulfur , stereochemistry , catalysis , alkyl , enzyme
2‐Alkoxy‐ and 4‐alkoxyuridines were converted into isocytidine and cytidine by reaction with ammonia at room temperature. Reaction with hydrogen sulfide produced 2‐thio‐ and 4‐thiouridine but the reaction was incomplete. The reaction may be helpful in the identification of alkylated pyrimidine nucleosides in DNA.