Premium
Carbon‐13 and proton NMR studies of 1,4‐benzodiazepines
Author(s) -
Haran R.,
Tuchagues J. P.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170725
Subject(s) - chemistry , oxazepam , nitrazepam , chlordiazepoxide , coupling constant , chemical shift , flunitrazepam , carbon 13 nmr , proton , benzodiazepine , computational chemistry , diazepam , organic chemistry , medicine , biochemistry , physics , receptor , particle physics , pharmacology , quantum mechanics
One bond and long range 1 H‐ 1 H, 1 H‐ 19 F, 13 C‐ 1 H and 13 C‐ 19 F coupling constants for six 1,4‐benzodiazepines are described. An unambiguous assignment of their carbon‐13 resonances is carried out based on chemical shift theory and on the analysis of the fine splittings caused by one bond and long range couplings. Chemical shift and coupling constant values are reported for diazepam, chlordiazepoxide, oxazepam, nitrazepam, chlonazepam and flunitrazepam.