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Syntheses with nitriles. 60 . Preparation of 4‐amino‐5‐cyano‐6‐phenylpyrimidines from 2‐amino‐1,1‐dicyano‐2‐phenylethene
Author(s) -
Mittelbach Martin,
Junek Hans
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170707
Subject(s) - chemistry , amino acid , dimethylformamide , nitrile , nuclear magnetic resonance spectroscopy , medicinal chemistry , stereochemistry , organic chemistry , solvent , biochemistry
The reaction of 2‐amino‐1,1‐dicyanobut‐1‐ene and 2‐amino‐1,1‐dicyano‐2‐phenylethene, respectively, with N,N ‐dimethylformamide dimethylacetal provided the corresponding ( N,N ‐dimethylaminomethylene)amino derivatives. 2‐[( N,N ‐Dimethylaminomethylene)amino]‐1,1‐dicyano‐2‐phenylethene was converted into 4‐amino‐5‐cyano‐6‐phenylpyrimidines by treatment with primary aliphatic and aromatic amines. The structure of the reaction products was confirmed by 13 C nmr spectroscopy.