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Thiophene systems. 4 . Selective syntheses of thieno[3,4‐ b ][1,4]‐ and [1,5]benzodiazepinones
Author(s) -
Press Jeffery B.,
Hofmann Corris M.,
Safir Sidney R.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170701
Subject(s) - chemistry , thiophene , alkoxy group , yield (engineering) , tricyclic , chloride , stereochemistry , combinatorial chemistry , organic chemistry , medicinal chemistry , alkyl , materials science , metallurgy
Novel syntheses of thiophene fused tricyclic systems 1 and 2 are reported. The methods use intermediates 4‐ethoxy‐3‐thiopheneamine, 4‐ethoxy‐3‐thiophenecarbonyl aside and 4‐ethoxy‐3‐thiophenecarbonyl chloride to effect selective, high yield syntheses of the target compounds in two steps. These methods allow preparation of thiophene systems without substitution at the normally reactive C‐1 and C‐3 positions.