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Reactions of 4‐chloroacetoacetic esters with thioureas
Author(s) -
Campaigne E.,
Selby T. P.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170622
Subject(s) - chemistry , thiourea , acetic acid , thiazole , hydrolysis , organic chemistry , pyrimidine , acid hydrolysis , stereochemistry
Several heterocyclic acetic acids and esters were synthesized by allowing the appropriate thiourea, ethylenethiourea or trimethylenethiourea to react with 4‐chloroacetoacetic esters, followed by acid hydrolysis to the hydrochlorides of the free acids. Both esters and acids of 2‐aminothiazole‐4‐acetic acid, 5,6‐dihydro‐imidazo[2,1‐ b ]thiazole‐3‐acetic acid and 6,7‐dihydro‐5 H ‐thiazolo[3,2‐ c ]pyrimidine‐3‐acetic acid were obtained.