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Selenium‐sulfur analogs 2. Synthesis and characterization of 4‐aralkyl‐1,2,3‐selenadiazoles and ‐1,2,3‐thiadiazoles
Author(s) -
Hanson Robert N.,
Davis Michael A.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170620
Subject(s) - chemistry , thiadiazoles , thionyl chloride , semicarbazide , alkylation , methyl iodide , organic chemistry , sulfur , hydrochloride , selenium , chloride , medicinal chemistry , catalysis
1 The3‐diketones 5 and 8 were alkylated with methyl iodide to give the nonenolizable diketones 6 and 9 which condensed with semicarbazide hydrochloride yielding the monosemicarbazones 7 and 10 . Cyclization with selenous acid or with thionyl chloride led to the corresponding 1,2,3‐selenadiazoles 3a , 4a , and 1,2,3‐thiadiazoles 3b , 4b .