Premium
Synthesis of some 3,7‐disubstituted quino[3,2‐ c ][1,8]naphthyridines
Author(s) -
Da Settimo Antonio,
Biagi Giuliana,
Primofiore Giampaolo,
Ferrarini Pier Luigi,
Livi Oreste,
Marini Anna Maria
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170616
Subject(s) - chemistry , nitrobenzene , condensation , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , physics , thermodynamics , catalysis
Abstract The preparation of some 3,7‐disubstituted‐5,6‐dihydroquino[3,2‐ c ][1,8]naphthyridines ( 6 ) by the condensation of 7‐substituted‐2,3‐dihydro‐1,8‐naphthyridin‐4‐(1 H )ones ( 5 ) with o ‐aminoacetophenone or o ‐aminobenzophenone is described. All the 5,6‐dihydroderivatives 6 were transformed into the fully aromatic compounds 7 by heating with nitrobenzene. Only a few quino[3,2‐ c ][1,8]naphthyridines were previously described.