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Methylation of 4‐phenyl‐1,2,3‐thiadiazole. Reaction of nucleophiles with N ‐methyl‐1,2,3‐thiadiazolium salts and the crystal structure of the products
Author(s) -
Auricchio S.,
Brückner S.,
Giunchi L. Malpezzi,
Kozinsky V. A.,
Zelenskaja O. V.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170614
Subject(s) - chemistry , nucleophile , morpholine , methylation , crystal structure , stereochemistry , medicinal chemistry , product (mathematics) , organic chemistry , catalysis , biochemistry , geometry , mathematics , gene
The methylation of 4‐phenyl‐1,2,3‐thiadiazole yields both N ‐methylated products. These react differently with nucleophiles. The structure of the product of the reaction with morpholine has been determined through X‐ray diffraction analysis.