Reissert compound studies. XXXVII. Attempts to form reissert compounds from quinazoline and cinnoline | Zendy

Bhattacharjee D. | Zendy; Popp F. D. | Zendy

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Reissert compound studies. XXXVII. Attempts to form reissert compounds from quinazoline and cinnoline

Author(s) -

Bhattacharjee D.,

Popp F. D.

Publication year - 1980

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570170611

Subject(s) - chemistry , cinnoline , quinazoline , trimethylsilyl cyanide , methyl iodide , medicinal chemistry , sodium hydride , benzoyl chloride , iodide , chloride , organic chemistry , sodium iodide , catalysis

Reaction of quinazoline with trimethylsilyl cyanide and benzoyl chloride gave 2,4‐dicyano‐1,3‐dibenzoyl‐1,2,3,4‐tetrahydroquinazoline as the major product. This compound undergoes monoalkylation with methyl iodide in the presence of sodium hydride. Reaction of cinnoline with trimethylsilyl cyanide and benzoyl chloride gave 1,2‐dibenzoyl‐4‐cyano‐1,2‐dihydrocinnoline.

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