Premium
Hydrazidoyl halides in synthesis of Δ 2 ‐1,3,4‐selenadiazolin‐5‐ones
Author(s) -
Hassaneen Hamdi M.,
Shetta Abdelfattah,
Shawali Ahmad S.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170606
Subject(s) - chemistry , acetic anhydride , halide , yield (engineering) , benzoyl chloride , nitrosation , pyridine , medicinal chemistry , ethanol , potassium , chloride , organic chemistry , catalysis , materials science , metallurgy
Reaction of hydrazidoyl halides 1‐5 with potassium selenocyanate in ethanol produces the corresponding 2,4‐disubstituted‐5‐iminoδ 2 ‐1,3,4‐selenadiazolines, 9‐13 respectively. Nitrosation of the latter yields the N ‐nitroso derivatives 14‐17 , which decompose upon refluxing in xylene to give 2,4‐disubstituted Δ 2 ‐1,3,4‐selenadiazolin‐5‐ones in good yield. Compounds 9‐13 give the respective N ‐acetyl derivatives 22‐26 and N ‐benzoyl derivatives 27‐31 with acetic anhydride and benzoyl chloride in pyridine.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom