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4‐(Arylaminothiocarbonyl)‐1‐(1‐ o ‐methoxyphenylcarbamido)‐ethylpiperazines as anticonvulsants
Author(s) -
Pandey Bhagwan R.,
Kumar Sushil,
Singh Shiva P.,
Parmar Surendra S.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170558
Subject(s) - chemistry , pentylenetetrazol , anticonvulsant , pharmacology , in vitro , stereochemistry , medicinal chemistry , epilepsy , biochemistry , neuroscience , psychology , medicine
Several 4‐(arylaminothiocarbonyl)‐1‐(1‐ o ‐methoxyphenylcarbamido)‐ethylpiperazines were synthesized and evaluated for their anticonvulsant activity against pentylenetetrazol‐induced seizures in mice. The ability of substituted piperazines to inhibit in vitro respiratory activity of rat brain homogenates was also determined to study their structure‐activity relationship.