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Reinvestigation of the reaction of ethyl 4,4,4‐trifluoroacetoacetate with aldehydes and ammonia
Author(s) -
Singh Baldev,
Lesher George Y.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170553
Subject(s) - chemistry , ammonia , organic chemistry , aldehyde , medicinal chemistry , catalysis
Reaction of ethyl 4,4,4‐trifluoroacetoacetate with aromatic aldehydes and ammonia gives diethyl 4‐aryl‐2,6‐dihydroxy‐2,6‐bis(trifluoromethyl)‐3,5‐piperidinedicarboxylates ( 4 ) instead of diethyl 4‐aryl‐1,4‐dihydro‐2,6‐bis(trifluoromethyl)‐3,5‐pyridinedicarboxylates ( 3 ) as reported previously (1).
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