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New heterocyclic systems. Benzo[4,5]cyclohepta[1,2‐ b ]pyrrole and benzo[5,6]cyclohepta[1,2‐ f ]pyrrolizidine derivatives
Author(s) -
Ackrell J.,
Franco F.,
Guzmàn R. Greenhouse A.,
Muchowski J. M.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170546
Subject(s) - chemistry , pyrrolizidine , pyrrole , moiety , acetic acid , medicinal chemistry , stereochemistry , organic chemistry
The synthesis of the polycyclic pyrrole acetic acids 9e, 13e and 13g by multistep processes from 1‐bromo‐4‐phenylbutan‐2‐one ( 6c ) is reported. An instance of the use of the 2‐chloroethyl moiety as a pyrrole nitrogen protecting group is described. The α‐methylaminoketone ( 6e ) was synthesised by a novel two step process from 6c and methyl N ‐methylformimidate ( 12 ).