New heterocyclic systems. Benzo[4,5]cyclohepta[1,2‐ b ]pyrrole and benzo[5,6]cyclohepta[1,2‐ f ]pyrrolizidine derivatives | Zendy

Ackrell J. | Zendy; Franco F. | Zendy; Guzmàn R. Greenhouse A. | Zendy; Muchowski J. M. | Zendy

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New heterocyclic systems. Benzo[4,5]cyclohepta[1,2‐ b ]pyrrole and benzo[5,6]cyclohepta[1,2‐ f ]pyrrolizidine derivatives

Author(s) -

Ackrell J.,

Franco F.,

Guzmàn R. Greenhouse A.,

Muchowski J. M.

Publication year - 1980

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570170546

Subject(s) - chemistry , pyrrolizidine , pyrrole , moiety , acetic acid , medicinal chemistry , stereochemistry , organic chemistry

The synthesis of the polycyclic pyrrole acetic acids 9e, 13e and 13g by multistep processes from 1‐bromo‐4‐phenylbutan‐2‐one ( 6c ) is reported. An instance of the use of the 2‐chloroethyl moiety as a pyrrole nitrogen protecting group is described. The α‐methylaminoketone ( 6e ) was synthesised by a novel two step process from 6c and methyl N ‐methylformimidate ( 12 ).

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