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Synthesis of 4 H ‐3,1‐benzoxazin‐4‐ones and 4‐(3 H )quinazolinones from anthranilic acids and their derivatives by the use of triphenyl phosphite and pyridine
Author(s) -
Rabilloud Guy,
Sillion Bernard
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170542
Subject(s) - chemistry , anthranilic acid , aniline , pyridine , benzoic acid , ring (chemistry) , organic chemistry , medicinal chemistry
A series of 2‐substituted 4 H ‐3,1‐benzoxazinones and 2,3‐disubstituted 4‐(3 H )quinazolinones have been synthesized in mild conditions by the use of triphenyl phosphite and pyridine as cyclising medium. Benzox‐azinones are produced either by ring closure of 2‐(acylamino)benzoic acids or in the reaction of benzoic acid with anthranilic acids. In the presence of aniline, the reaction leads to quinazolinones.