2‐Imidazolines. IV  . 1‐Aryl‐2‐alkylthio‐4,5‐ diamino‐4,5‐dihydroimidazoles. Synthesis and properties | Zendy

Meola Stefania | Zendy; Rivera Elisabetta | Zendy; Stradi Riccardo | Zendy; Gioia Bruno | Zendy

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2‐Imidazolines. IV . 1‐Aryl‐2‐alkylthio‐4,5‐ diamino‐4,5‐dihydroimidazoles. Synthesis and properties

Author(s) -

Meola Stefania,

Rivera Elisabetta,

Stradi Riccardo,

Gioia Bruno

Publication year - 1980

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570170536

Subject(s) - chemistry , raney nickel , pyrolytic carbon , medicinal chemistry , aryl , diamine , imidazoline receptor , organic chemistry , catalysis , pyrolysis , alkyl , medicine

1,2‐Diimmonium salts ( 1 ) react with S ‐substituted isothioureas ( 3 ) yielding 2‐alkylthio‐4,5‐diamino‐4,5‐dihydroimidazoles ( 4 ), which under mild pyrolytic conditions afforded 2‐alkylthio‐5‐aminoimidazoles ( 7 ). Imidazolines ( 4 ) and imidazoles ( 7 ) were easily desulfurated with Raney nickel affording 4,5‐diamino‐4,5‐dihydroimidazole ( 9 ) and 5‐aminoimidazole ( 10 ), respectively.

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