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Synthesis of phenylurethans of a pyrazolidinylcarbinol as anticonvulsant agents
Author(s) -
Kornet Milton J.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170524
Subject(s) - chemistry , anticonvulsant , pharmacology , seizure threshold , epilepsy , psychology , neuroscience , medicine
Eleven phenylurethans were prepared from 1,2‐dimethyl‐3‐hydroxymethylpyrazolidine and various phenyl isocyanates. Anticonvulsant screening revealed that two of the phenylurethans exhibited moderate activity in the maximal electroshock seizure (MES) test in mice.