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Synthesis of some 5 H ‐imidazo[4,5‐ e ]‐as‐triazin‐6‐(7 H )ones (6‐azapurin‐8‐ones)
Author(s) -
Yoneda Fumio,
Higuchi Masatsugu,
Nitta Yoshihiro
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170505
Subject(s) - chemistry , decarboxylation , sodium hydroxide , medicinal chemistry , organic chemistry , catalysis
Treatment of 1,3‐dialkyl‐7‐azalumazine derivatives with alcoholic sodium hydroxide caused a benzylic acid type rearrangement followed by decarboxylation and oxidation by air to give the corresponding 5,7‐dialkyl‐5 H ‐imidazo[4,5‐ e ]‐as‐triazin‐6‐(7 H )ones (7,9‐dialkyl‐6‐azapurin‐8‐ones).