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An improved synthesis of 3,5‐disubstituted isoxazoles and pyrazoles from C (α), O ‐dilithiooximes and C (α), N ‐dilithiophenylhydrazones
Author(s) -
Fulmer Tammy D.,
Dasher Lisette P.,
Bobb Bonni L.,
Wilson Jana D.,
Sides Kimberly L.,
Beam Charles F.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170437
Subject(s) - chemistry , stereochemistry , medicinal chemistry , combinatorial chemistry
C (α), O ‐Dilithiooximes and C (α), N ‐dilithiophenylhydrazones were prepared using an excess of lithium diisopropylamide (1:3). Condensation with esters followed by acid cyclization gave isoxazoles and pyrazoles.