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New practical synthesis of prazosin
Author(s) -
Honkanen Erkki,
Pippuri Aino,
Kairisalo Pekka,
Thaler Heinrich,
Koivisto Maija,
Tuomi Sirpa
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170436
Subject(s) - prazosin , chemistry , hydrochloride , combinatorial chemistry , organic chemistry , antagonist , receptor , biochemistry
A new four step synthesis of prazosin, 2‐[4‐(2‐furoyl)piperazin‐l‐yl]‐4‐amino‐6,7‐dimethoxyquinazoline, has been described. The method is also adaptable for the preparation of other substituted 4‐aminoquinazolines. The yields are good in every step and the reactions are performed with ease. Prazosin hydrochloride of high purity is obtained directly in the last step.