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Adducts of 2‐aminothiophenol with acetylenic nitriles or esters and their conversion into benzothiazoles and/or 1,4‐benzothiazines
Author(s) -
Liso Gaetano,
Trapani Giuseppe,
Berardi Vincenza,
Latrofa Andrea,
Marchini Paolo
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170435
Subject(s) - chemistry , adduct , thio , dimethyl sulfoxide , organic chemistry , sulfoxide , boiling , medicinal chemistry
The reaction between 2‐aminothiophenol 1 and acetylenic nitriles or esters 2a‐d leads to the vinyl thio‐ethers 3a‐d. The conversion of 3 into benzothiazoles 8 and/or 1,4‐benzothiazines 9 , in boiling dimethyl sulfoxide, has been achieved. A possible pathway involving benzothiazolines 5 as key intermediates is suggested.