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A convenient and general synthesis of 2‐amino‐1,3,4‐thiadiazoles. Dehydration of acylthiosemicarbazides with methanesulfonic acid
Author(s) -
Kress Thomas J.,
Costantino Silvio M.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170340
Subject(s) - methanesulfonic acid , chemistry , thiadiazoles , dehydration , alkyl , aryl , toluene , organic chemistry , amino acid , molar ratio , biochemistry , catalysis
2‐Amino‐5‐alkyl and 2‐amino‐5‐aryl‐1,3,4‐thiadiazoles were prepared by the dehydration of 2‐acylthiosemicarbazides with molar equivalents of methanesulfonic acid in refluxing toluene. The synthesis appears to be general.