Premium
Triphenylphosphonium‐alloxan betaines
Author(s) -
Adams William E.,
Heindel Ned D.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170328
Subject(s) - alloxan , chemistry , adduct , oxygen , oxygen atom , medicinal chemistry , stereochemistry , organic chemistry , diabetes mellitus , molecule , endocrinology , medicine
Alloxan and 1,3‐dimethylalloxan react with triarylphosphines to generate zwitterionic adducts involving the phosphorus and the C‐5 carbonyl oxygen atoms of alloxan. The adducts, unlike alloxan, did not induce permanent hyperglycemia but one analog did effect a transient rise in blood glucose.