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(2‐Alkyl‐1,4‐benzodioxan‐2‐yl)carboxylic acids as potential hypolipidemic agents
Author(s) -
Salimbeni Aldo,
Manghisi Elso
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170313
Subject(s) - chemistry , alkyl , potassium permanganate , potassium , organic chemistry , medicinal chemistry , stereochemistry
1,2‐Diphenols reacted with 2‐alkyl‐3‐chloro‐1,2‐epoxypropane to give a mixture of 1,4‐benzodioxane, V, and 1,5‐benzodioxepine, VII, alcohols. From potassium permanganate oxidation of benzodioxane compounds V the corresponding (2‐alkyl‐1,4‐benzodioxan‐2‐yl)carboxylic acids II were obtained. In a preliminary pharmacological evaluation benzodioxane acids II did not show any effect on plasma cholesterol, while producing a moderate lowering of triglycerides.