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Syntheses and reactions of some 4,5‐dihaloimidazole‐2‐carboxylic acid derivatives
Author(s) -
Dirlam John P.,
James Richard B.,
Shoop Eleanor V.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170244
Subject(s) - chemistry , pyrazine , imidazole , carboxylic acid , medicinal chemistry , organic chemistry
The preparation of 5 H ,10 H ‐diimidazo[1,2‐ a :1′,2′‐ d ]pyrazine‐5,10‐dione ( 2a ) and its 2,3,7,8‐tetrabromo‐ and 2,3,7,8‐tetrachloro‐ analogs ( 2b and 2c , respectively) is reported. These dimers, when allowed to react with various anilines, afford imidazole‐2‐carboxamides ( 3a‐c ).
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